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Efficient biosynthesis of CuO nanoparticles with potential cytotoxic activity

Nesrine M. R. Mahmoud, Hadeer I. Mohamed, Somia B. Ahmed, and Sultan Akhtar

Basic Science Department, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia



Received: 16 July 2019  Accepted: 26 February 2020


Biogenic CuO nanoparticles (CuO-NPs) were greenly synthesized utilizing two precursors of waste plant extracts, namely pomegranate peel [PP] and date stones [DS], to enhance its cytotoxic activity. The biogenic CuO-NPs produced from pomegranate peel extract [PP-CuO-NPs] have been found in an excessively small nanosized structures [~ 6 nm] compared to that prepared from the date stones extract [~ 20 nm] D-CuO-NPs. The two products [PP-CuO-NPs and D-CuO-NPs] obtained were fully characterized. The agglomeration and crystal formation of biogenic CuO-NPs were investigated by transmission electron microscopy, scanning electron microscopy, and X-ray diffraction analysis. Fourier transform infrared spectroscopy and thermogravimetric analysis–derivative thermogravimetric analysis were utilized to determine the existence of working groups absorbed on the biogenic CuO-NPs surface, while the dispersion stability of CuO-NPs was assessed through zeta potential test. The validity of the biogenic CuO-NPs as cytotoxic agent was applied against human breast cancer [MCF7] cell lines and compared with the normal BJ1 cell line. The results demonstrated a discriminative inhibition of cancer cell growth of MCF7, particularly by using PP-CuO, decreasing to nearly 0.0%.

Keywords: Copper oxide; Green synthesis; Cytotoxicity; Nanoparticles; Date stones; Pomegranate peel

Full paper is available at

DOI: 10.1007/s11696-020-01120-6


Chemical Papers 74 (9) 2825–2835 (2020)

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