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Ultrasound-assisted rapid synthesis of β-aminoketones with direct-type catalytic Mannich reaction using bismuth(III) triflate in aqueous media at room temperature

S. Arda Ozturkcan, Kadir Turhan, and Zuhal Turgut

Department of Chemistry, Organic Chemistry Division, Faculty of Science, Yildiz Technical University, 34220 Esenler, Istanbul, Turkey



Abstract: An innovative, powerful, efficient and relatively rapid method was developed to synthesise various β-aminoketone derivatives from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes via ultrasound-assisted direct-type catalytic Mannich reaction using bismuth(III) triflate in water. Good yields of the desired β-aminoketones were obtained at room temperature by ultrasound-assisted reaction within 1–2 h. The major advantages of the proposed method are undemanding conditions, easy operation, low toxicity, shorter reaction time, anti selectivity and higher yields in comparison with conventional methods.

Keywords: sonochemistry – β-aminoketones – direct-type Mannich reaction – bismuth(III) triflate – green innovation

Full paper is available at

DOI: 10.2478/s11696-011-0097-z


Chemical Papers 66 (1) 61–66 (2012)

Tuesday, June 18, 2024

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