ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Design, synthesis, and biological evaluation of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties as active insecticidal agents
Zaibo Yang, Pei Li, Yinju He, Jun Luo, Jing Zhou, Yinghong Wu, and Liantao Chen
School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun, People’s Republic of China
Received: 25 July 2019 Accepted: 26 November 2019
To discover and develop novel active molecules, in this study, a series of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties were designed and synthesized. Bioassay results revealed that some of the target compounds possessed good insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), respectively, which were even better than those of the commercial insecticidal agents chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. The results favored our rational design intention and provide a new class of small-molecule inhibitors available for the development of active insecticidal agents targeting P. xylostella, V. aphids, and E. vitis.
Keywords: Pyrethrin; trans-Ethyl chrysanthemate; 1,3,4-Oxadiazole; Thioether; Insecticidal activity
Full paper is available at www.springerlink.com.
Chemical Papers 74 (5) 1621–1632 (2020)