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Efficient synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone: key intermediate for preparing Coenzyme Q

Yong-Fu Qiu, Bin Lu, Yi-Yu Yan, Wan-Yue Luo, Jin Wang, and Xiao Hu

Yancheng Teachers University, Yancheng, People’s Republic of China

 

E-mail: jaxdon@126.com

Abstract: The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in an excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination, methoxylation and oxidation reactions. An 80% overall yield was demonstrated on a multi-gram scale.

Keywords: Coenzyme Q ; 1,4-Benzoquinone ; Bromination 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-019-00826-6

 

Chemical Papers 73 (11) 2745–2748 (2019)

Friday, December 06, 2019

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