ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
4β-Isocyanopodophyllotoxins: valuable precursors for the synthesis of new podophyllotoxin analogues
Ying-Qian Liu, Lin-Hai Li, Wen-Qun Li, Gang Feng, and Liu Yang
School of Pharmacy, Lanzhou University, Lanzhou, 730000 China
Abstract: A new and efficient method for the synthesis of novel 4β-isocyanopodophyllotoxins as a valuable building block for the synthesis of versatile bioactive podophyllotoxin analogues under both classical and ultrasonic conditions was developed. In general, significant improvements in rates of reaction and yields of sonochemical reactions relative to the classical ones were observed.
Keywords: 4β-isocyanopodophyllotoxins – anticancer drugs – multicomponent reactions – ultrasound
Full paper is available at www.springerlink.com.
Chemical Papers 65 (5) 739–742 (2011)
Thursday, August 22, 2019