ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Silicon-based thiourea-mediated and microwave-assisted thio-Michael addition under solvent-free reaction conditions
Kamalakannan Prabakaran, Machindra Gund, Tae Kyu Kim, Euh Duck Jeong, Chae Young Oh, Fazlur-Rahman Nawaz Khan, and Jong Sung Jin
Organic & Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, 632 014 India
Abstract: Silicon-based thiourea (SiliaBond® Thiourea) (Si-THU), a heterogeneous catalyst, has been applied to the highly selective C-S bond formation via Michael addition of thiols to α,β-unsaturated carbonyl compounds under solvent-free conditions at 55–60°C. The thio-Michael addition products were obtained in an excellent yield under optimised conditions. This methodology involving a metal-free as well as a metal scavenger catalyst has been found to be an alternative method for the thio-Michael addition reaction.
Keywords: SiliaBond® Thiourea – solvent-free Michael reaction – thioethers
Full paper is available at www.springerlink.com.
Chemical Papers 65 (5) 707–713 (2011)
Monday, February 24, 2020