ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases
Zorica D. Petrović, Jelena Đorović, Dušica Simijonović, Snežana Trifunović, and Vladimir P. Petrović
University of Kragujevac, Kragujevac, Serbia
Abstract: N-Salicylidene and N-vanillidene anil Schiff bases SB-1–5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV–Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1–5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.
Keywords: Anti-LOX activity ; Cytotoxic activity ; Iron-coordinating properties ; UV–Vis spectrophotometry ; IR spectroscopy
Full paper is available at www.springerlink.com.
Chemical Papers 72 (9) 2171–2180 (2018)