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Design, synthesis of novel oxazolidino-amides/sulfonamides conjugates and their impact on antibacterial activity

Yarlagadda Bharath, Gopi Reddy Alugubelli, Reddymasu Sreenivasulu, and Mandava. V. Basaveswara Rao

Vignan’s Foundation for Science, Technology and Research University (VFSTR University), Guntur, India

 

E-mail: vbrmandava@yahoo.com

Abstract: In view of generating new compounds for future drug development, we have synthesized oxazolidinones library of aryl amides and aryl sulfonamide derivatives. These compounds were screened in vitro against panel of susceptible and resistant Gram-positive (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Pseudomonas aeruginosa), fungi (Candida albicans) strains, and Mycobacterium tuberculosis (Mtb). Among them, 10d and 11a compounds have been evaluated against 12 fungal strains and have displayed significant antimycotic activities approximately 37 folds more potent than fluconazole.

Keywords: Oxazolidinones ; Antitubercular activity ; Antimycobacterial activity ; EDC ; Anti-fungal activity 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-017-0298-1

 

Chemical Papers 72 (2) 457–468 (2018)

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