ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Domino synthesis of quinazolin-4-yl thioureido alkanoates
Walid Fathalla and Pavel Pazdera
Port-Said University, Port Said, Egypt
Abstract: A simple convenient protocol for the synthesis of methyl 2-[3-(2-(substituted phenyl)quinazolin-4-yl)thioureido] alkanoates is described. It involves the domino reaction of various amino acid esters with imidoylisothiocyanates in ethyl acetate to afford quinazoline thiourea derivatives in excellent yields. Short reaction time, mild condition, simple work up, high yields, and pure products are the major advantages of this protocol. The number of isolated pure compounds from this simple protocol is 24. The starting imidoyl isothiocyanates were prepared from the corresponding benzanilides and were purified by flash chromatography.
Keywords: Amino acid esters ; Chemoselective reactions ; Intramolecular hydrogen bond ; Domino reaction
Full paper is available at www.springerlink.com.
Chemical Papers 72 (1) 209–219 (2018)
Wednesday, August 10, 2022