ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
An efficient synthesis of β-methoxycarbonyl-γ-butyrolactones
Ruirui Li, Zhiqiang Li, Lan Jiang, and Zhengning Li
College of Environmental and Chemical Engineering, Dalian University, Dalian, China
Abstract: β-Methoxycarbonyl-γ-butyrolactones bearing a γ-aromatic substituent were prepared via copper-catalyzed reductive aldol addition/lactonization domino reactions of ketones with α,β-unsaturated dicarboxylate esters and a silane under ambient temperature. The reaction has advantage of using readily available reagents, mild conditions and high efficiency.
Keywords: Copper hydride; Domino reaction; γ-Lactone; Synthesis; Catalysis
Full paper is available at www.springerlink.com.
Chemical Papers 71 (10) 1825–1828 (2017)