ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis of novel coumarin substituted amide derivatives and their antibacterial activities
Mei-Hang Chen, Dao-Wang Lu, Xun Zhang, Zeng-Yan Zhou, Xiao-Bin Wang, and Hua Shu
School of Material and Chemistry Engineering, Tongren University, Tongren, China
Abstract: A series of novel coumarin substituted amide derivatives were synthesized and evaluated for their antibacterial activities. Result indicated that compounds 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n, 3o and 3q exhibited excellent antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas citri subsp. Citri (Xcc) in vitro, which were better than those of commercial agricultural antibacterial thiodiazole-copper. The title compounds with electron-withdrawing group showed better antibacterial activities than those of compounds with electron-donating group, and the title compounds bearing the same substituent group exhibited better antibacterial activities against Xcc than antibacterial activities against Xoo.
Keywords: Coumarin; Amide derivatives; Synthesis; Antibacterial activity
Full paper is available at www.springerlink.com.
Chemical Papers 71 (9) 1579–1586 (2017)
Monday, September 28, 2020