ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Microwave-assisted synthesis of 1,4-bis(difluoromethyl)benzene
Dong-Hui Pan, Tong-Zhen Wang, and Guo-Min Xiao
School of Chemistry and Chemical Engineering, Southeast University, Nanjing, People’s Republic of China
Abstract: A fast, mild, and practical microwave-assisted protocol for synthesis of 1,4-bis(difluoromethyl)benzene from 1,4-bis(dichloromethyl)benzene and KF was developed. The new protocol increased the yield and reduced the reaction time significantly in contrast to the conventional heating procedure. Also, the synergistic effect of a composite phase transfer catalyst was studied.
Keywords: Microwave-assisted synthesis, 1,4-bis(difluoromethyl)benzene, Phase transfer catalyst fluorination
Full paper is available at www.springerlink.com.
Chemical Papers 71 (7) 1249–1254 (2017)