ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
Irmina Wojciechowska, Aleksandra Wojciechowska, Karolina Wieszczycka, Przemysław Aksamitowski, Joanna Zembrzuska, and Grzegorz Framski
Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznan, Poland
Abstract: LC–MS/MS method to determine hydrophobic N-alkyloxy substituted amidines: N-(2-ethylhexyloxy)pyridine-2-carboximidamide, N-(2-ethylhexyloxy)pyridine-3-carboximidamide, N-(2-ethylhexyloxy)pyridine-4-carboximidamide, N-decyloxy pyridine-2-carboximidamide, N-decyloxypyridine-3-carboximidamide and N-decyloxypyridine-4-carboximidamide was developed and validated in terms of linearity, precision and accuracy. The developed method was successfully applied to monitor and control the synthesis process. The experimental data points indicated that the straight chain alkyl bromide reacted most rapidly than branched alkyl bromide and the enhancement of the reaction efficiency strongly depended on reaction temperature.
Keywords: N-alkyloxypyridinecarboximidamide; O-alkylation reaction; LC–MS/MS; Reaction kinetics
Full paper is available at www.springerlink.com.
Chemical Papers 71 (5) 953–960 (2017)