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Chemoselective synthesis of 1,2-disubstituted benzimidazoles in lactic acid without additive

Zhi-Yu Yu, Jia Zhou, Qiu-Sheng Fang, Ling Chen, and Zhi-Bin Song

State Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China



Abstract: Lactic acid is recognised as a biocompatible medium for the chemoselective synthesis of the 1,2-disubstituted benzimidazole scaffold via a direct one-pot cyclocondensation of o-phenylenediamine with aldehydes. Various 1,2-disubstituted benzimidazole derivatives were successfully synthesised with high selectivity with good to excellent yields without any additional catalyst or additive. Most products could be isolated by a simple filtration after completion of the reactions. Satisfactory results were also obtained from multi-gram scale reactions.

Keywords: chemoselective – 1,2-disubstituted benzimidazoles – lactic acid – green synthesis

Full paper is available at

DOI: 10.1515/chempap-2016-0056


Chemical Papers 70 (9) 1293–1298 (2016)

Thursday, November 21, 2019

SCImago Journal Rank 2018
International Conference on Coordination and Bioinorganic Chemistry
46th International Conference of SSCHE
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