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facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

İbrahim Esirden, Erhan Başar, and Muharrem Kaya

Chemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100 Kütahya, Turkey.

 

E-mail: muharrem.kaya@dpu.edu.tr

Abstract: The present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper(I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst.

Keywords: 5-substituted 1H-tetrazoles – copper(I) chloride – sodium azide – [3 + 2] cycloaddition – aryl nitriles

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2015-0124

 

Chemical Papers 69 (9) 1231–1236 (2015)

Thursday, May 23, 2024

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