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Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus

Ilona Bakai-Bereczki, Mihály Herczeg, Bernadett György, Lieve Naesens, and Pál Herczegh

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1., 4032 Debrecen, Hungary

 

E-mail: bereczki.ilona@pharm.unideb.hu

Abstract: In order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.

Keywords: ristocetin aglycone – influenza virus – antiviral activity – sialoconjugate

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2015-0116

 

Chemical Papers 69 (8) 1136–1140 (2015)

Wednesday, June 23, 2021

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