ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Practical synthesis of 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone
Jin Wang, Shuo Li, Tao Yang, Jin-Rong Zeng, and Jian Yang
Kunming University of Science and Technology, Kunming, Yunnan, 650224, China
Abstract: 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone (V) was prepared with a 75 % yield by means of a reaction sequence starting from 2,3,4,5-tetramethoxytoluene via Blanc chloromethylation reaction, Kornblum oxidation, NaBH4 reduction and ceric ammonium nitrate oxidation. The procedure is operationally simple and amenable to gram-scale synthesis.
Keywords: coenzyme Q – idebenone – Kornblum oxidation – ceric ammonium nitrate oxidation
Full paper is available at www.springerlink.com.
Chemical Papers 69 (3) 486–489 (2015)