ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly
 

Practical synthesis of 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone

Jin Wang, Shuo Li, Tao Yang, Jin-Rong Zeng, and Jian Yang

Kunming University of Science and Technology, Kunming, Yunnan, 650224, China

 

E-mail: woongching@gmail.com

Abstract: 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone (V) was prepared with a 75 % yield by means of a reaction sequence starting from 2,3,4,5-tetramethoxytoluene via Blanc chloromethylation reaction, Kornblum oxidation, NaBH4 reduction and ceric ammonium nitrate oxidation. The procedure is operationally simple and amenable to gram-scale synthesis.

Keywords: coenzyme Q – idebenone – Kornblum oxidation – ceric ammonium nitrate oxidation

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2015-0001

 

Chemical Papers 69 (3) 486–489 (2015)

Tuesday, August 20, 2019

IMPACT FACTOR 2018
1.246
SCImago Journal Rank 2018
0.274
SEARCH
Advanced
VOLUMES
International Conference on Coordination and Bioinorganic Chemistry
46th International Conference of SSCHE
© 2019 Chemical Papers