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Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

Da-Wei Zhang, Yu-Min Zhang, Yi-Liang Zhang, Tian-Qi Zhao, Hong-Wei Liu, Yuan-Ming Gan, and Qiang Gu

College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, China

 

E-mail: guq@jlu.edu.cn

Abstract: An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

Keywords: bis(indolyl)methanes – microwave synthesis – bis(indolyl)methanes containing isoxazolering – SiO2 solid support – solvent-free

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2015-0036

 

Chemical Papers 69 (3) 470–478 (2015)

Tuesday, April 16, 2024

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