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Solvent-free synthesis of β-enamino ketones and esters catalysed by recyclable iron(III) triflate

Cheng-Liang Feng, Ning-Ning Chu, Shu-Guang Zhang, Jin Cai, Jun-Qing Chen, Hua-You Hu, and Min Ji

Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, 210096, Nanjing, China



Abstract: A novel application of highly stable Fe(OTf)3 as an efficient catalyst for the synthesis of a variety of β-enamino ketones and esters under solvent-free conditions is described. Notably, this protocol of a “green synthesis”, which produced β-enamino ketones and esters by the reaction of a variety of β-dicarbonyl compounds and primary amines, exhibits attractive properties including high yields, short reaction periods, lower loading of catalyst and chemo- and regio-selectivity. In addition, the catalyst was easily recovered from the reaction system and readily reused with minimal loss of activity.

Keywords: β-dicarbonyl compounds – amines – enaminones – iron(III) triflate – solvent-free

Full paper is available at

DOI: 10.2478/s11696-014-0544-8


Chemical Papers 68 (8) 1097–1103 (2014)

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