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Synthesis and insecticidal activity of 6,8-dichloro-quinazoline derivatives containing a sulfide substructure

Jian Wu, Song Bai, Min Yue, Li-Jun Luo, Qin-Cai Shi, Juan Ma, Xian-Li Du, Sheng-Hong Kang, Deyu Hu, and Song Yang

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, 550025, China

 

E-mail: wujian2691@126.com

Abstract: A series of 6,8-dichloro-quinazoline derivatives bearing a sulfide group was synthesized and characterized via 1H NMR, 13C NMR, IR and elemental analyses. All the compounds were tested for their insecticidal activity against Plutella xylostella in vitro. The results indicate that the synthesized compounds possess good insecticidal activity. Among these compounds, Vc, Vi, Vj, Vk and Vm displayed 75 %, 85 %, 80 %, 70 % and 63 % activities, respectively. These may prove useful as insecticidal agents.

Keywords: quinazoline derivative – sulfide substructure – insecticidal activity – synthesis

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-014-0540-z

 

Chemical Papers 68 (7) 969–975 (2014)

Thursday, December 12, 2019

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