ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly
 

Synthesis of new eburnamine-type alkaloid via direct hydroalkoxylation

Xiong Liu, Dong-Liang Yang, Jia-Jia Liu, Jing Zhou, and Nana Zhao

Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China

 

E-mail: liujj0903@163.net

Abstract: This study concerns the preparation of a new eburnamine-type alkaloid, methyl (3α,14β,15β,16α)-17,18-didehydro-14,15-dihydroeburnamine-15-methoxy-14-carboxylate (VIII). This alkaloid was prepared from (+)-17,18-dehydroapovincamine (V) using Lewis acid and/or ion exchange resin as catalyst. The hydroalkoxylation reaction of V with methanol was investigated in terms of catalyst, solvent, temperature, and time of reaction. A one-pot method for synthetising this alkaloid was established. The optimal conditions for the reaction are discussed.

Keywords: eburnamine-type alkaloid – catalyst – hydroalkoxylation

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-013-0512-8

 

Chemical Papers 68 (6) 816–822 (2014)

Friday, October 18, 2019

IMPACT FACTOR 2018
1.246
SCImago Journal Rank 2018
0.274
SEARCH
Advanced
VOLUMES
International Conference on Coordination and Bioinorganic Chemistry
46th International Conference of SSCHE
© 2019 Chemical Papers