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“Green synthesis” of benzothiazepine library of indeno analogues and their in vitro antimicrobial activity

Ashok P. Acharya, Rahul D. Kamble, Snehalkumar D. Patil, Shrikant V. Hese, Omprakash S. Yemul, Sudhakar G. Patil, Shivshankar N. Halale, and Bhaskar S. Dawane

School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, MS, India, 431606

 

E-mail: rdkamble143@gmail.com

Abstract: A novel series of indeno-benzothiazepine derivatives was synthesised via a “green” route. Synthesis of these compounds involves the treatment of dinucleophiles such as 2-aminobenzenethiols with α,β-unsaturated ketones in poly(oxyethylene) (poly(ethylene glycol), PEG-400) catalysed by acetic acid. The synthone α,β-unsaturated ketones were obtained by Claisen-Schmidt condensation of indan-1-one with substituted pyrazole-2-carbaldehydes prompted by bleaching earth (pH 12.5) as catalyst and PEG-400 as “green” reaction solvent. Screening of all the synthesised compounds for antimicrobial activity revealed that most of these compounds exhibited moderate to significant antimicrobial activity.

Keywords: indeno-benzothiazepine – PEG-400 – bleaching earth – antimicrobial activity

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-013-0496-4

 

Chemical Papers 68 (5) 719–724 (2014)

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