ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis of brushite nanoparticles at different temperatures
Sujata Singh, Vaishali Singh, Saroj Aggarwal, and Uttam Kumar Mandal
University School of Basic and Applied Sciences, GGS Indraprastha University, Kashmere Gate, Delhi, 110403, India
Received: 25 July 2009 Revised: 1 October 2009 Accepted: 8 October 2009
Abstract: Phase pure, stable nanocrystalline brushite particles with average diameter in the range of 23–87 nm were obtained by the
reverse microemulsion technique employing a mixture of surfactants (Aliquat 336 & Tween 80) as template directing agents,
and calcium nitrate tetrahydrate and biammonium hydrogen phosphate as precursors. Particle sizes and morphologies were tuned
by adjusting the reaction parameters, precursor concentration and temperature. FTIR, TEM, and XRD were used to characterize
morphological changes of as synthesized nanoparticles. FTIR and XRD analyses confirmed the formation of brushite nanoparticles.
Variations in the reaction temperature resulted in changes in the particle morphology and distribution. At high temperatures
(60°C), the sample exhibited high monodispersity and spherical morphology with the average grain size of 42 nm. At low temperatures
(6°C), nanoflakes were formed. The results suggest that a reverse microemulsion system provides facile media for control of
the phase and morphology of nanoscale calcium phosphate biominerals. A mechanism providing an insight into the formation of
brushite particles has also been proposed.
Keywords: reverse microemulsion - brushite - mixed surfactants - nanoparticle - morphology
Full paper is available at www.springerlink.com.
Chemical Papers 64 (4) 491–498 (2010)