ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
A novel, stereoselective and practical protocol for the synthesis of 4β-aminopodophyllotoxins
Ying-Qian Liu, Lin-Hai Li, Liu Yang, and Hong-Yu Li
MOE Key Laboratory of Arid and Grassland Ecology, School of Life Sciences, Lanzhou, 730000, China
Received: 1 October 2009 Revised: 26 November 2009 Accepted: 2 December 2009
Abstract: Ritter reaction of podophyllotoxins with chloroacetonitrile and subsequent cleavage of the chloroacetyl group in the resulting
chloroacetamide with thiourea under both classical heating and ultrasonic conditions is an efficient procedure for the synthesis
of 4β-aminopodophyllotoxins. In general, significant improvements in the rates of reaction and yields of the sonochemical reactions
relative to the classical heating reactions were observed.
Keywords: 4β-aminopodophyllotoxins - anticancer drugs - Ritter reaction - ultrasound
Full paper is available at www.springerlink.com.
Chemical Papers 64 (4) 533–536 (2010)