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A novel method for N-alkylation of aliphatic amines with ethers over γ-Al2O3

Hangeng Chen, Tao Zhang, Chao Qian, and Xinzhi Chen

Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou, 310027, China

 

E-mail: supmoney@163.com

Received: 10 September 2009  Revised: 29 January 2010  Accepted: 1 February 2010

Abstract: A novel and simple method for the N-alkylation of amines with different ethers as alkylating reagents has been developed, using cheap γ-Al2O3 as the catalyst at atmospheric pressure in the temperature range of 260–320°C. For example, the reaction of equimolar amounts of morpholine and diethyl ether gave N-ethylmorpholine quantitatively. The present catalytic system is applicable to the N-alkylation of both primary and secondary amines. Since only water is generated as byproduct, the protocol proved to be eco-friendly and atom-economic.

Keywords: ethers - amines -  N-alkylation - atom-economic

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-010-0033-7

 

Chemical Papers 64 (4) 537–540 (2010)

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