ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
Biljana Dekić, Vidoslav Dekić, Niko Radulović, Rastko Vukićević, and Radosav Palić
Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia
Received: 6 July 2009 Revised: 15 September 2009 Accepted: 21 September 2009
Abstract: A series of new coumarin derivatives has been synthesized by condensation of 4-chloro-3-nitrocoumarin and the appropriate arylamine and sulfonamide in ethyl acetate in the presence of triethylamine. The synthesized compounds were screened for their in vitro antimicrobial activity against thirteen strains of bacteria and three fungal/yeast strains using disk diffusion assays. They were shown to possess a wide range of activities from almost completely inactive compounds to medium active ones. (4-[(5-Chloropyridin-2-yl)amino]-3-nitro-2H-chromen-2-one) showed similar activity against Klebsiella pneumoniae as tetracycline.
Keywords: 4-arylamino-3-nitrocoumarins - 4-chloro-3-nitrocoumarin - NMR spectroscopy - antimicrobial activity
Full paper is available at www.springerlink.com.
Chemical Papers 64 (3) 354–359 (2010)