ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Color stability of morphine salts

J. Balán and E. Csere

Slovakofarma, Hlohovec

Abstract: It has been shown by the effect of N, atm. O, and H₂O₂ that the discoloration of morphine (I) salts is oxidative, caused by Fe catalysis and org. impurities. Cu has no catalytic effect. I salts can be stabilized by a mixt. of 6% NaHSO₃ and 5% of ascorbic acid at pH about 3.0. Solns. of I sulfates are much more stable than of I-HCl.

Full paper in Portable Document Format: 77a409.pdf (in Slovak)

Chemical Papers 7 (7) 409–419 (1953)