ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Anticonvulsive effect of derivatives of phenylacetylcarbamides

Ľ. Buran, F. Selecký, and P. Šefčovič

Slovak Academy of Sciences, Bratislava

Abstract: The effect was investigated of phenylacetylcarbamide (I), diphenylacetylcarbamide (II), α-bromophenylacetylcarbamide (III), and phenylacetylthiocarbamide (IV) in rats in preventing shock caused by pentamethylenetetrazole. I, 600 mg./kg. or higher, was 100% effective; III, 1500mg./kg., decreased mortality of the rats by 90%, but did not prevent convulsions. Up to 1500 mg./kg. II and IV were not effective.

Full paper in Portable Document Format: 87a404.pdf (in Slovak)

Chemical Papers 8 (7) 404–409 (1954)