ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
An amperometric sensor for uric acid based on ordered mesoporous carbon-modified pyrolytic graphite electrode
Yonggen Ma, Guangzhi Hu, Shijun Shao, and Yong Guo
Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China
Received: 23 December 2008 Revised: 25 March 2009 Accepted: 15 April 2009
Abstract: A novel amperometric sensor for uric acid based on ordered mesoporous carbon modified pyrolytic graphite electrode was developed.
Uric acid oxidation was easily catalyzed by this electrode in a phosphate buffer solution at pH 7.0, with an anodic potential
decrease about 140 mV compared to bare pyrolytic graphite electrode. The uric acid level was determined by the amperometric
method, at a constant potential of 0.31 mV, the catalytic current of uric acid vs. its concentration showed a good linearity
in the range of 1.0 × 10−6−1.0 × 10−4 mol L−1, with a correlation coefficient of 0.999. The detection limit was 4.0 × 10−7 mol L−1. The proposed method could be effectively used for uric acid amperometric sensing in human urine.
Keywords: amperometric sensor - uric acid - ordered mesoporous carbon - pyrolytic graphite electrode
Full paper is available at www.springerlink.com.
Chemical Papers 63 (6) 641–645 (2009)