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An amperometric sensor for uric acid based on ordered mesoporous carbon-modified pyrolytic graphite electrode

Yonggen Ma, Guangzhi Hu, Shijun Shao, and Yong Guo

Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China



Received: 23 December 2008  Revised: 25 March 2009  Accepted: 15 April 2009

Abstract: A novel amperometric sensor for uric acid based on ordered mesoporous carbon modified pyrolytic graphite electrode was developed. Uric acid oxidation was easily catalyzed by this electrode in a phosphate buffer solution at pH 7.0, with an anodic potential decrease about 140 mV compared to bare pyrolytic graphite electrode. The uric acid level was determined by the amperometric method, at a constant potential of 0.31 mV, the catalytic current of uric acid vs. its concentration showed a good linearity in the range of 1.0 × 10−6−1.0 × 10−4 mol L−1, with a correlation coefficient of 0.999. The detection limit was 4.0 × 10−7 mol L−1. The proposed method could be effectively used for uric acid amperometric sensing in human urine.

Keywords: amperometric sensor - uric acid - ordered mesoporous carbon - pyrolytic graphite electrode

Full paper is available at

DOI: 10.2478/s11696-009-0076-9


Chemical Papers 63 (6) 641–645 (2009)

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