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Copper determination using ICP-MS with hexapole collision cell

Vladislav Chrastný and Michael Komárek

Department of Applied Chemistry and Chemistry Teaching, University of South Bohemia, Studentská 13, 370 05 České Budějovice, Czech Republic



Received: 21 November 2008  Revised: 18 January 2009  Accepted: 26 January 2009

Abstract: Determination of copper using inductively coupled plasma mass spectrometry (ICP-MS) suffers from polyatomic overlays originating from Na+ and Mg2+ matrix elements due to the formation of 40Ar23Na+ and 40Ar25Mg+ in the mass-to-charge ratios of 63 and 65, respectively. The collision/reaction cell technology belongs to the most modern methods used to overcome polyatomic interferences. Gas-filled collision/reaction cell can cause an additional mass bias effect influencing analytical precision of the method. In this study, the additional mass bias effect of the hexapole collision/reaction cell ICP-MS was studied on an example of n(65Cu)/n(63Cu) isotope ratio. As a result, a method for suppressing polyatomic interference on the mass-to-charge ratio of 63 and 65 was introduced and additional mass bias of the collision/reaction cell was lowered to an acceptable level.

Keywords: ICP-MS - hexapole collision/reaction cell - additional mass bias -  n(65Cu)/n(63Cu) isotope ratio - polyatomic interferences

Full paper is available at

DOI: 10.2478/s11696-009-0057-z


Chemical Papers 63 (5) 512–519 (2009)

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