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The preparation of antiarrhythmic compounds

P. Šefčovič, K. Babor, and V. Kaláč

Slovak Academy of Sciences, Bratislava

 

Abstract: The Na salts of the diterpene acids treated with N,N-disubstituted 2-aminoethyl chloride in dry benzene gave the following esters (b. p. base, °/mm. Hg, m.p., hydrochloride, [α]21 base, n21D base, and % yield given): abietic acid: dimethylaminoethyl, 203-5°/0.4 and 196-8°/0.3, 187-91°, -33.5, 1.5234. 74.5; diethylaminoethyl, 222-6°/0.6, 161-4°, -40.0, 1.5226, 92.0; piperidinoethyl, 231-5°/0.4, 185-9°, -40.5, 1.5324, 91.6; morpholinoethyl, 225-6°/0.9, 160-2°, -39.6, 1.5298, 88.0; dehydroabietic acid: dimethylaminoethyl, 207-9°/0.7, 207-9, +30.0, 1.5262, 94.2; diethylaminoethyl, 203-5°/0.5, 153-4°, +27.5, 1.5248, 92.5, piperidinoethyl, 218-21°/0.4, 212-14°, +27.5, 1.5363, 89.7; and morpholinoethyl, 225°/0.5, 216-19°, +25.0, 1.5282, 84.6. Their hydrochlorides were effective in treatment of arrhythmic conditions of the heart.

Full paper in Portable Document Format: 158a554.pdf (in Slovak)

 

Chemical Papers 15 (8) 554–557 (1961)

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