ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Adsorption and release of terbinafine hydrochloride: Effects of adsorbents, additives, pH, and temperature
Zuzana Vitková, Jarmila Oremusová, and Oľga Greksáková
Department of Galenic, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
Received: 18 March 2008 Revised: 9 September 2008 Accepted: 22 September 2008
Abstract: The paper describes results obtained within the study of factors affecting the process of an antifungal drug — terbinafine
hydrochloride adsorption on two different adsorbents — charcoal and silicagel. The effects of the adsorbent area, pH value,
temperature and additives (polymers — methyl cellulose and hydroxypropyl cellulose) were analyzed and their impact on the
adsorption of terbinafine was derived. The increase of pH and temperature, and the presence of additives decreased the amount
of terbinafine adsorbed on the adsorbents. Terbinafine is currently applied both perorally and topically. Hydrogels, i.e.
compositions of a drug, additives and water, are, due to their advantageous properties, preferred topical dosage forms. Mass
fraction of additives of 1 % to 4 % were studied from the view point of drug release. This study shows that both the sort
and the concentration of polymers influence the drug release from hydrogels significantly.
Keywords: terbinafine - adsorption - pH influence - adsorption isotherms - hydrogel - drug release
Full paper is available at www.springerlink.com.
Chemical Papers 63 (3) 345–350 (2009)