ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Electrospray ionization mass spectra of pentoses, hexoses, and 2-deoxy-2-fluoro-d
Peter Brúder, Fedor Macášek, and Emília Búriová
Department of Nuclear Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-1, SK-84215 Bratislava, Slovakia
Received: 14 January 2008 Revised: 10 April 2008 Accepted: 17 April 2008
Abstract: Electrospray ionization (ESI) mass spectra of hexoses, pentoses, and 2-deoxy-2-fluoro-d-glucose (FDG) were investigated and compared using liquid chromatography/mass spectroscopy (LC/MS). 18F-FDG is one of the most widely used radiopharmaceuticals. This work is aimed at the possible interpretations of ESI mass
spectra and at the comparison of various pentoses (arabinose, ribose, xylose), and hexoses (glucose, fructose, galactose,
mannose) which can be formed during the 18F-FDG’s synthesis or decomposition. As a result, nine major associates were found in the positive and four in the negative
mass spectra of all examined saccharides of which intensities and mass can be used with their retention times to determine
the saccharide. M · NH4+ and M · COOH− were identified as the most stable associates.
Keywords: monosaccharides - mass spectroscopy - liquid chromatography - 2-deoxy-2-fluoro-d-glucose
Full paper is available at www.springerlink.com.
Chemical Papers 62 (6) 547–552 (2008)