ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Preparation of trisodium
Fridrich Gregáň, Milan Melicherčík, Juraj Gregáň, and Milan Remko
Department of Chemistry, Faculty of Natural Sciences, Matej Bell University, Tajovského 40, SK-974 01 Banská Bystrica, Slovak Republic
Received: 9 July 2007 Revised: 15 October 2007 Accepted: 12 November 2007
Abstract: Trisodium O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl) diphosphates were synthesized from sodium dimethylamido-O-(2-cyanoethyl) phosphate and O-alkyl-and O-aryl phosphoric acids. While in the previously described method, sodium hydroxide was used for the preparation of O-phenyl diphosphate, in our current work, we present an improved protocol, where sodium methoxide is used to increase the
yields of O-alkyl and O-aryl diphosphates. The structures of final compounds were determined by 1H NMR, 31P NMR, and IR spectroscopy. The sodium O-alkyl- and O-aryl diphosphate salts prepared by this method may be used for the study of biological activity of diphosphate analogues.
Keywords: trisodium O-alkyl diphosphates - trisodium O-aryl diphosphates - pyrophosphate -
1H NMR -
31P NMR - IR
Full paper is available at www.springerlink.com.
Chemical Papers 62 (2) 223–226 (2008)