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ISSN electronic edition: 1336-9075
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Preparation, structure, and antibacterial activity of some 1,5-diphenyl-3-pyrazinyl-2-pyrazoline derivatives

J. Zámocká, D. Dvořáčková, J. Heger, A. Nagy, and D. Mlynarčík

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Komenský University, 880 34 Bratislava

 

Abstract: Thirteen new l,5-diphenyl-3-pyrazinyI-2-pyrazolines were prepared by the reaction of halogen, alkoxy, and hydroxy derivatives of 2',5'-diazachalcones with Phenylhydrazine under the catalytic action of 10% aqueous solution of tetramethylammonium hydroxide. The structures of the synthesized compounds were proved by their i.r. and 'H-n.m.r. spectra. The prepared compounds (1 % solutions in ethylene glycol dimethyl ether) were found to be active against Staphylococcus aureus OXFORD and Escherichia coli.

Full paper in Portable Document Format: 344a550.pdf

 

Chemical Papers 34 (4) 550–555 (1980)

Friday, June 14, 2024

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