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Synthesis and antifungal activity of alkyland arylsulfanylpyridinylguanidines

K. Palát, G. Braunerová, M. Miletín, and V. Buchta

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

 

E-mail: palat@faf.cuni.cz

Received: 8 January 2007  Revised: 14 June 2007  Accepted: 18 June 2007

Abstract: A series of alkyl- and arylsulfanylpyridylguanidines was synthesized and their antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi. Compounds with an alkylsulfanyl substitution have antifungal activity, which improves with increasing length of the aliphatic chain.

Keywords: alkylsulfanylpyridylguanidines - halogenopyridylguanidines - antifungal activity

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-007-0070-z

 

Chemical Papers 61 (6) 507–511 (2007)

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