ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis and antifungal activity of alkyland arylsulfanylpyridinylguanidines
K. Palát, G. Braunerová, M. Miletín, and V. Buchta
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
Received: 8 January 2007 Revised: 14 June 2007 Accepted: 18 June 2007
Abstract: A series of alkyl- and arylsulfanylpyridylguanidines was synthesized and their antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi. Compounds with an alkylsulfanyl substitution have antifungal activity,
which improves with increasing length of the aliphatic chain.
Keywords: alkylsulfanylpyridylguanidines - halogenopyridylguanidines - antifungal activity
Full paper is available at www.springerlink.com.
Chemical Papers 61 (6) 507–511 (2007)