ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
A new phenanthroindolizidine alkaloid from Tylophora indica
Mini Dhiman, Amit Khanna, and Sreedharannair L. Manju
Special Projects Analytical Chemistry, Piramal Healthcare Ltd. 1, Goregaon (E), 400063, Mumbai, India
Abstract: A new phenanthroindolizidine alkaloid, 3-O-demethyl tylophorinidine (VI), was isolated from the aerial (leaves and stem) parts of Tylophora indica and characterized using different spectral techniques. Gel chromatography and reverse phase preparative HPLC were used for sample purification. The new alkaloid, VI, was screened for anticancer activity against a panel of different cancer cell lines and it showed significant anticancer activity with IC50 value in the range of 0.89–1.40 μM.
Keywords: Tylophora indica – asclepiadaceae – phenanthroindolizidine alkaloids – anticancer
Full paper is available at www.springerlink.com.
Chemical Papers 67 (2) 245–248 (2013)
Monday, February 17, 2020