ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
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Synthesis of some substituted tetrazolylacetic acids

Ľ. Janda and Z. Votický

Drug Research Institute, CS-900 01 Modra

 

Abstract: Alkylation of 5-(5-bromo-2-furyl)-l#-tetrazole with ethyl bromoacetate afforded a mixture of ethyl 5-(5-bromo-2-furyl)-l-tetrazolylacetate and ethyl 5-(5-bromo-2-furyl)-2-tetrazolylacetate; these were chromatographically separated and the ester substituted in position 1 was the substrate for the nucleophilic substitution with 4-substituted thiophenols. The resulting ethyl 5-[5-(4-R-phenylthio)-2-furyl]-l-tetrazolylacetates were hydrolyzed to corresponding acids.

Full paper in Portable Document Format: 431a63.pdf

 

Chemical Papers 43 (1) 63–71 (1989)

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