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Synthesis of Nicotinoyl Hydrazones, Their N-Oxide Analogs and the Corresponding 3-(5-Aryl-1,3,4-oxadiazol-2-yl)pyridine Derivatives as Potential Hypoglycemic Agents

M. M. Girges, M. A. Hanna, M. Berghot, and D. Rasala

Mansoura Faculty of Science, Mansoura University, 355 16 Mansoura, Egypt

 

Abstract: A series of nicotinoyl hydrazones and their N-oxide analogues have been synthesized. Subsequent ring closure afforded the 3-(5-aryl-1,3,4-oxadiazol-2-yl)pyridine derivatives. The structures of the prepared compounds were established by means of spectral data. Fourteen of the hitherto prepared compounds, when screened on the albino rats at an oral dose of 100 mg/kg, reduced the blood sugar level to a significant extent.

Full paper in Portable Document Format: 464a272.pdf

 

Chemical Papers 46 (4) 272–277 (1992)

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