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Synthesis and Biological Activity of Some 2-Substituted Quinazolin-4-ones

K. Špirková, S. Stankovský, A. Mrvová, and Ľ. Čipák

Department of Organic Chemistry, Faculty of Chemical Technology, Slovak University of Technology, SK-812 37 Bratislava

 

Abstract: The nonclassical antifolates have been prepared by nucleophilic substitution of bromine in 2-bromomethyl-3H-quinazolin-4-one by nitrogen and oxygen nucleophiles. IR and 1H  NMR spectra, 13C  NMR data of selected compounds, basic antibacterial and cytotoxic activities are presented.

Full paper in Portable Document Format: 534a272.pdf

 

Chemical Papers 53 (4) 272–275 (1999)

Thursday, April 18, 2024

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