ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Three-component, one-pot synthesis of 3,4-dihydropyrimidin-2-(1 H )-ones catalyzed by bromodimethylsulfonium bromide
A. Shaabani and A. Maleki
Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran
Received: 1 November 2006 Revised: 20 February 2007 Accepted: 21 February 2007
Abstract: An efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives by one-pot three-component condensation reaction between an alkyl or aryl aldehyde, a 1,3-dicarbonyl compound, and urea or thiourea in the presence of catalytic amount of bromodimethylsulfonium bromide has been developed. The condensation product was obtained in excellent yields in refluxing ethanol and easily separated from the reaction mixture and purified.
Keywords: bromodimethylsulfonium bromide - dihydropyrimidinones - multicomponent reaction - synthesis - catalysis
Full paper is available at www.springerlink.com.
Chemical Papers 61 (4) 333–336 (2007)
Thursday, December 09, 2021