ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Enantioselective extraction of mandelic acid enantiomers by L -dipentyl tartrate and β -cyclodextrin as binary chiral selectors
F. P. Jiao, X. Q. Chen, W. G. Hu, F. R. Ning, and K. L. Huang
School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China
Received: 30 September 2006 Revised: 6 February 2007 Accepted: 12 February 2007
Abstract: A new binary chiral selector system effective for the enantioselective extraction of racemic mandelic acid is presented. While L-dipentyl tartrate and β-cyclodextrin had a very low enantioselectivity as single selectors, a preferential extraction of D-mandelic acid to the organic phase was found in the binary selector system. Using decanol as organic solvent and pH of a phoshate buffer equal to 2.3, the distribution coefficients of D-and L-mandelic acids as high as 14.9 and 7.0, respectively, and the enantioselectivity value of 2.1 were found at optimum concentration of β-cyclodextrin.
Keywords: enantiomer - mandelic acid - enantioselective extraction - chiral selector - L-dipentyl tartrate - β-cyclodextrin
Full paper is available at www.springerlink.com.
Chemical Papers 61 (4) 326–328 (2007)