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Synthesis and Cyclization Reactions with Quinolinyl Keto Esters. II. Synthesis of Novel 3-Diazolylquinolinones and their Enzymic Activity

M. M. Ismail and H. M. Mohamed

Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy 11711 Cairo, Egypt

 

E-mail: mmismail@chemist.com

Received: 11 September 2003

Abstract: Ethyl 4-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-2,4-dioxobutyrate, ethyl 5-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)pyrazole-3-caboxylate and their acid hydrozide derivatives have been prepared and reacted with hydrazines, o-phenylenediamine, triethyl orthoformate, carbon disulfide, and thiosemicarbazides in order to obtain some new 3-substituted quinolin-2-ones as: pyrazolines, isoxazolines, imidazoles, pyrazolotriazines, thiadiazoles, and triangles. All the newly prepared compounds revealed the potent effect on increasing reactivity of cellobimse. The structure of the new compounds was established upon their elemental analyses, IR, 1H NMR, and mass fragmentation spectra.

Full paper in Portable Document Format: 592a127.pdf

 

Chemical Papers 59 (2) 127–138 (2005)

Tuesday, March 19, 2024

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