ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly

Solution combustion method for synthesis of ZnO NPs from Syzygium hemisphericum bark extract and a comparative analysis of the same with the crude bark extract for biomedical applications

C. H. Sushmitha, G. Krishnakumar, and K. Meghana Navada

Department of Applied Botany, Mangalore University, Mangalagangothri, India



Received: 23 August 2023  Accepted: 10 January 2024


This study is aimed at the bio-fabrication of zinc oxide nanoparticles (SHB@ZnO NPs) from the aqueous bark extract of Syzygium hemisphericum (SHBW) and their comparative analysis for biomedical applications. The FT-IR spectra reveal the Zn–O bond by the appearance of peaks at 411 cm−1 and 398 cm−1. Further, the peak at 370 nm in UV–Vis spectra analysis affirms the same. The X-ray diffraction reveals the ultrafine structure of NPs (10 nm). The morphology of the NPs depends on fuel load as analyzed from FESEM images. A prodigious antioxidant activity of SHBW was observed compared to ZnO NPs with IC50 values of 8.877 ± 0.14 µg/mL and 236.74 ± 2.55 µg/mL, respectively. SHBW showed a markable α-amylase (37.68 ± 2.33 µg/mL) and α-glucosidase (37.68 ± 2.33 µg/mL) inhibitory activity compared to the SHB@ZnO-20. The antibacterial activity of synthesized NPs was observed against a wide range of strains. The HRBC membrane stabilization assay was carried out to substantiate the non-toxic nature toward human RBC’s (71.30% for SHBW and 46.96% for SHB@ZnO-20). The anticancer activity of ZnO NPs utilizing a definite volume of reducing agent was analyzed against A431 cancer cell lines which revealed that the cell viability decreased as NPs concentration (64.80% at 50 µg/mL) increased.

Graphical abstract

Keywords: Syzygium hemisphericum; ZnO nanostructures; Skin cancer suppressor; Antidiabetic; Antibacterial; GC–MS

Full paper is available at

DOI: 10.1007/s11696-024-03319-3


Chemical Papers 78 (6) 3443–3462 (2024)

Monday, June 24, 2024

SCImago Journal Rank 2021
European Symposium on Analytical Spectrometry ESAS 2022
© 2024 Chemical Papers