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Integrating MXene/MWCNTs into aptasensor capable of ultrasensitive quantification of cTnI towards the diagnosis of acute myocardial infarction

Tao Jinsong, Han Jin, Li Weizhang, Cui Junyou, Li Jian, Cao Xiangming, and Zhang Hua

Department of Cardiology, The Affiliated Jiangyin Hospital of Medical College of Southeast University, Jiangyin, China

 

E-mail: jjtaojs@163.com

Received: 7 June 2023  Accepted: 14 September 2023

Abstract:

The development of a pragmatic biosensor for diagnosing acute myocardial infarction (AMI) is of paramount significance. However, the detection of cardiac Troponin I (cTnI) presents formidable challenges owing to the intricate composition and scant concentration of cTnI in clinical samples. Therefore, we propose an innovative approach employing an aptamer biosensor predicated on MXene/multi-wall carbon nanotubes (MWCNTs) to discern cTnI. By integrating the MXene/MWCNTs nanomaterial, our aptasensor manifests remarkable amplification effects, thereby enabling an extensive detection range spanning from 10 to 106 pg/mL, while attaining an unparalleled detection sensitivity with an exceptionally low limit of 6.21 pg/mL. Furthermore, our aptasensor exhibits favourable selectivity, reproducibility, and stability. Moreover, our aptasensor showcases a robust clinical correlation equation of y = 1.202x + 0.0147, accompanied by an R2 value of 0.9797. A notable p-value discrepancy is observed between the AMI and healthy control groups. Remarkably, the area under the curve (AUC) achieved amounts to 0.981, with a sensitivity of 0.938 and specificity of 0.923. These outstanding attributes, coupled with its exceptional clinical performance, position our aptasensor as the optimal choice for the practical monitoring of acute myocardial infarction (AMI) disease.

Keywords: MXene/MWCNTs; Aptasensor; cTnI; Acute myocardial infarction

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03304-w

 

Chemical Papers 78 (5) 3205–3212 (2024)

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