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Synthesis and identification of Zn(BTC)-(MOF) as a metal–organic framework for its application in the impedimetric determination of thyroxine hormone in human blood samples

Hassan Keypour, Rahman Karimi-Nami, Jamal Kouhdareh, Somayyeh Babaei, Ammar Maryamabadi, Sedigheh Alavinia, Mohammad Taher Rezaei, and Sina Shokri

Department of Inorganic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran



Received: 26 February 2023  Accepted: 11 September 2023


This study discusses the determination of thyroxine hormone in blood serum samples by a novel MOF composite electrode. The used MOF was Zn(BTC)-(MOF) which was constructed from 1,3,5-benzenetricarboxylic acid ligand (BTC) and zinc ions in DMF solvent. Using cysteine as the linker, the MOF was plated on the surface of a gold electrode, formerly covered by a layer of gold nanoparticles immersed in conductive polymer polypyrrole (PPy). Different analytical methods, such as FTIR, XRD, SEM, EIS, CV, and BET, were utilized to investigate the morphology and performance of the prepared materials. The modified electrode exhibited excellent electrocatalytic ability to reduce thyroxine without interference from common coexisting substances such as different salts. The fabricated electrode has been successfully used to determine thyroxine in a linear concentration range of 10–210 nM with a detection limit of 8 nM.

Graphical abstract

Keywords: Metal organic frameworks; Thyroxine hormone; Electrochemically modified electrode; Cyclic voltammetry; Electrochemical impedance spectroscopy

Full paper is available at

DOI: 10.1007/s11696-023-03080-z


Chemical Papers 77 (12) 7633–7642 (2023)

Tuesday, May 28, 2024

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