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Gold nanoparticle deposited electrochemical sensor for hyaluronic acid detection

Benay Perk, Yudum Tepeli Büyüksünetçi, and Ülkü Anık

Faculty of Science, Chemistry Department, Mugla Sitki Kocman University, Kotekli-Mugla, Turkey



Received: 7 December 2022  Accepted: 10 March 2023


In this study, gold nanoparticle (AuNP)-modified carbon paste electrode (CPE)-based electrochemical sensor for hyaluronic acid (HA) detection was developed. The change in the electrode surface area and the increase in HA electrochemical signals after modification with AuNP were investigated. Afterwards, pH and scan rate effects on developed HA sensor response were extensively studied and analytical characteristics were examined. As a result, limit of detection and limit of quantification values of developed sensor were found as 0.0034 mg/100 mL HA and 0.0115 mg/100 mL HA, respectively. Meanwhile, reproducibility and relative standard deviation values for 0.08 mg/100 mL HA were also calculated and found as 2.04% (n = 3). For the interference study, ascorbic acid, glucose, acetylcholine and H2O2 were chosen as interfering substances, and in the presence of cocktail of these molecules, the recovery values were estimated as 102.79% (onefold) 97.88% (twofold) and 100.30% (threefold). Also, AuNP/CPE sensor was applied for HA detection in dermatological HA serum, sheet mask and hair serum. Acceptable recovery values varying between 99.86 and 100.70% were obtained with real samples, which shows the applicability of the developed sensor.

Keywords: Gold nanoparticles; Hyaluronic acid; Electrochemical sensor; Cosmetics

Full paper is available at

DOI: 10.1007/s11696-023-02781-9


Chemical Papers 77 (8) 4319–4329 (2023)

Thursday, June 13, 2024

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