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Electrochemical preparation and the characterizations of poly(3,5-diamino 1,2,4-triazole) film for the selective determination of pyridoxine in pharmaceutical formulations

Santhy Antherjanam and Beena Saraswathyamma

Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, India



Received: 18 October 2022  Accepted: 10 March 2023


This work describes the synthesis and characterization of a polymeric film of 3,5-diamino 1,2,4-triazole on a pencil graphite electrode for the selective sensing of pyridoxine (PY). The PGE was modified using the electropolymerization process by the potentiodynamic method. The polymerized electrode (PDAT/PGE) was characterized by IR, SEM, AFM, cyclic voltammetry, and electrochemical impedance spectroscopy. PY undergoes irreversible oxidation at 0.79 V on PDAT/PGE in phosphate buffer of pH 5. Using the differential pulse voltammetric technique (DPV), PY showed a linear range from 5 to 950 μM with a lower detection limit of 2.96 μM. The PDAT/PGE was applied for the analytical determination of PY in pharmaceutical tablets with good recovery.

Graphical abstract

Keywords: Pyridoxine; Voltammetry; 3,5-diamino 1,2,4-triazole

Full paper is available at

DOI: 10.1007/s11696-023-02777-5


Chemical Papers 77 (8) 4285–4296 (2023)

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