ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Simple selenide-phosphoramidite as chiral ligand for Pd-catalyzed asymmetric allylic alkylation reactions

Bin Feng, Yuan-Yuan Qin, Yaru Xie, Yonggang Li, and Ge-Yun You

Guangxi Key Laboratory of Urban Water Environment, College of Chemistry and Environmental Engineering, Baise University, Baise, China

E-mail: yougeyun1988@163.com

Received: 13 November 2022  Accepted: 27 December 2022

Abstract:

A simple selenide-phosphoramidite ligand was prepared in two steps with high yield under mild reaction condition, the activity of which was examined in Pd-catalyzed asymmetric allylic alkylation reaction. The results indicated that the ratio of ligand to metal played a key role in the reaction, and generally good yields and moderate enantioselectivities (up to 90% yield, 72% ee) were obtained under the optimal reaction conditions.

Keywords: Chiral ligands; Selenide; Phosphoramidite; Asymmetric allylic alkylation reaction

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02652-9

Chemical Papers 77 (5) 2929–2933 (2023)