ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Rational design of AIE-based carbazole derivatives for lipid droplet-specific imaging in living cells
Hui Wang, Xuebin Shen, Jiayi Ge, Yi Deng, Feiyang Ding, Zhiyu Wang, Wenya Zhu, Lei Hu, Jing He, and Xiaoxia Gu
School of Pharmacy, Wannan Medical College, Wuhu, People’s Republic of China
Received: 15 June 2022 Accepted: 21 September 2022
The visualization of lipid droplets (LDs) plays a significant role in understanding relevant diseases. Herein, a sequence of novel carbazole derivatives (L1–L9) with D-A-π-D structure have been designed and synthesized, of which the photophysical properties were systematically investigated combining with theoretical calculation. It was found that all the compounds exhibited an obvious aggregation-induced (AIE) emission behavior. In particular, compound L7 displayed the most favorable AIE property with a distinct fluorescence enhancement in ethanol/H2O mixtures. Furthermore, the living cell experiments revealed that only compound L7 could target the lipid droplets with high specificity and good biocompatibility. In brief, the lipid droplets targeting ability and the AIE characteristic render compound L7 a promising candidate for the specific visualization of lipid droplets at the cellular level.
Keywords: Lipid droplets; Carbazole derivative; Aggregation-induced emission property; Fluorescent probes; Cell imaging
Full paper is available at www.springerlink.com.
Chemical Papers 77 (1) 563–569 (2023)
Friday, December 08, 2023